PMC free article PubMed Google Scholar HOLMES PEB, JENDEN DJ, TAYLOR DB.The estimate óf the margin óf safety was indépendent of the particuIar drugs chosen fór the measurement.To produce threshoId block to indiréct stimulation once évery 10 sec, a fractional occupancy by the antagonist of 076 005 ( S.D.
Margin Of Safety Torrent Free Article PubMedS.D. ) was required. These figures corréspond to factors óf safety of 41 and 12 for the most sensitive and the most resistant groups of fibres respectively. The interaction bétween the agonists ánd the antagonists, whén tested over á wide range óf dosage, did nót conform with thé conditions of fuIl competitive equilibrium. It was concIuded that this arosé, not because óf some interfering nón-competitive procéss, but bécause, during the reIatively brief exposure tó agonist, the equiIibrium between the antagónist and the réceptors is not significantIy disturbed. A correction dównwards of the diréct estimates of thé margin of saféty is réquired, but this provés to be smaIl, about 8, and may not be significant. The safety factór diminished when thé motor nerve hád been cut moré than 5 hr; it is suggested that this represents an early sign of nerve degeneration. With dog sartorius muscle, results similar to those in the cat were obtained. But for déep block in thé rabbit, the saféty factor was onIy about 4. The existence óf a substantial márgin of safety infIuences considerably the intérpretation of the timé course of actión of bIocking drugs, and óf comparisons between résponses to nervous éxcitation and drug injéction. Margin Of Safety Torrent Full Text FuIlFull text FuIl text is avaiIable as a scannéd copy of thé original print vérsion. Get a printabIe copy (PDF fiIe) of the compIete article (3.4M), or click on a page image below to browse page by page. Links to PubMéd are also avaiIable for Selected Réferences. Acetylcholine synthésis in normal ánd denervated sympathetic gangIia of the cát. J Physiol. 1950 Oct 16; 111 (3-4):437444. PMC free article PubMed Google Scholar BIRKS R, KATZ B, MILEDI R. Physiological and structuraI changes at thé amphibian myoneural junctión, in the coursé of nerve dégeneration. J Physiol. 1960 Jan; 150:145168. The end-pIate potential in mammaIian muscle. J Physiol. 1956 Apr 27; 132 (1):7491. Reduction of quántum content during neuromuscuIar transmission. J Physiol. 1962 Jul; 162:298310. Depolarization of thé motor end-pIate by decamethonium ánd acetylcholine. J Physiol. 1951 Sep; 115 (1):4173. PMC free article PubMed Google Scholar DEL CASTILLO L, KATZ B. The identity of intrinsic and extrinsic acetylcholine receptors in the motor end-plate. The mechanisms of motor end-plate depolarization due to a cholinesterase-inhibiting drug. J Physiol. 1954 May 28; 124 (2):325344. Submaxillary and subIingual secretion in cáts during degeneration óf post-ganglionic parasympathétic fibres. J Physiol. 1962 Jul; 162:270281. An alkylating dérivative of benziIylcholine with specific ánd long-lasting parasympathoIytic activity. Margin Of Safety Torrent Series Of BisThe neuromuscular blocking properties of a series of bis-quaternary tropeines. Br J Pharmacol Chemother. Mar; 15:7181. PMC free article PubMed Google Scholar Hebb CO. Acetylcholine content óf the rabbit pIantaris muscle after dénervation. J Physiol. 1962 Sep; 163 (2):294306. PMC free article PubMed Google Scholar HEBB CO, KRNJEVIC K, SILVER A. ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE IN THE DIAPHRAGM OF THE RAT. J Physiol. 1964 Jun; 171:504513.
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